Surgical Pathology Criteria

Tubular Adenosis of the Breast

Differential Diagnosis

Tubular Carcinoma Tubular Adenosis
Stellate, infiltrating Diffuse
Frequent apical snouts No apical snouts
Ducts with frequent pointed ends Infrequent pointed ends
Empty lumens Eosinophilic secretion present in at least some lumens
Stroma desmoplastic Stroma usually hypocellular or fat
No myoepithelial cells Myoepithelial cells

Microglandular Adenosis Tubular Adenosis
Uniformly round lumens Predominantly tubular
Cytoplasm frequently clear Cytoplasm eosinophilic
No myoepithelial layer Myoepithelial cells present
Secretion eosinophilic Secretion eosinophilic or basophilic

Apocrine Adenosis Tubular Adenosis
Variable but round glands Tubules
Apocrine lumenal differentiation and in some cases squamous metaplasia present No squamous or apocrine metaplasia
Frequently merges with adenomyoepithelioma No association with adenomyoepithelioma

Sclerosing Adenosis Tubular Adenosis
Lobular architecture Haphazard
Crowded glands Dispersed
Most lumens compressed Lumens vary from compressed to dilated

Tubular Adenosis Tubular Adenoma
Diffuse, infiltrative Circumscribed
Surrounds normal elements Mass displaces normal elements
Haphazardly scattered tubules Densely packed tubules
Abundant fibrous or fatty stroma Scant stroma
These are similar in name only

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