Surgical Pathology Criteria–

Tubular Adenoma of the Breast

Differential Diagnosis

Lactating Adenoma Tubular Adenoma
Prominent lactational change Lumenal secretion may be present, but cytoplasmic vacuoles lacking
These may represent the same lesion under different physiologic conditions

Microglandular Adenosis Tubular Adenoma
Poorly circumscribed pattern Circumscribed
Surrounds normal elements Mass displaces normal elements
No myoepithelial cell layer Myoepithelial cell layer present
Haphazardly scattered tubules Densely packed tubules
Abundant fibrous or fatty stroma Scant stroma

Sclerosing Adenosis Tubular Adenoma
Localized but not sharply circumscribed Sharply circumscribed
Distorted, compressed ducts Uniform patent ducts
Cellular stroma Scant stroma

Adenomatous Transformation of Fibroadenoma Tubular Adenoma
Areas of typical fibroadenoma stroma Scant stroma
Variable tubules Uniform tubules
Areas typical of tubular adenoma may be found within fibroadenomas

Ductal Adenoma Tubular Adenoma
Frequent prominent sclerosing stroma Scant stroma
Fibrous capsule No capsule
Localized but not completely circumscribed Completely sharply circumscribed
Papillomatosis or adenomatosis with variable small glands Uniform glands

Nipple Adenoma Tubular Adenoma
Frequent prominent sclerosing stroma Scant stroma
Localized but not completely circumscribed Completely sharply circumscribed
Papillomatosis or adenomatosis with variable small glands Uniform glands

Tubular Carcinoma Tubular Adenoma
Stellate infiltrative pattern Circumscribed
No myoepithelial layer Myoepithelial cells present
These are similar in name only

Tubular Adenosis Tubular Adenoma
Diffuse, infiltrative Circumscribed
Surrounds normal elements Mass displaces normal elements
Haphazardly scattered tubules Densely packed tubules
Abundant fibrous or fatty stroma Scant stroma
These are similar in name only

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