Surgical Pathology Criteria

Infiltrating Syringomatous Adenoma of the Nipple

Differential Diagnosis

Infiltrating Syringomatous Adenoma of the Nipple Low Grade Adenosquamous Carcinoma
Involves dermis and subcutis Parenchymal lesion
No metastases reported Infrequent metastases reported
  • Some consider these to be the same entity in different locations
  • Histologic appearance is identical
  • Small numbers of cases and differences due to superficiality could account for the difference in behavior reported
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    Nipple Adenoma Infiltrating Syringomatous Adenoma of the Nipple
    May have compressed ducts at edges but predominantly papillomatous Irregular, frequently compressed lumens throughout
    Localized although not completely circumscribed Infiltrative
    Stroma non-reactive Desmoplastic stroma
    Squamous metaplasia may be present in papillomatosis resulting in confusion with syringomatous adenoma

     

    Tubular Carcinoma Infiltrating Syringomatous Adenoma of the Nipple
    Uniform, gaping tubules Irregular, frequently compressed lumens
    Tubules frequently have pointed ends Tubules frequently have long comma-shaped tails
    No squamous differentiation At least focal squamous differentiation
    No myoepithelial component Myoepithelial cells present around tubules

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