Focal Pregnancy-like Change of the Breast
Definition
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Focal lactational change in a non-lactating, non-pregnant patient
Alternate/Historical Names
Diagnostic Criteria
- The patient must be currently non-lactating and non-pregnant
May be of any age - Dilated acini lined by abundant pale vacuolated cytoplasm
Lumenal cytoplasmic blebs Nuclei frequently contained in apical blebs - Nuclei typically small, round, uniform
- Four cases reported with cytologic atypia, of unknown clinical significance (Shin)
Increased nucleo/cytoplasmic ratio, pleomorphic nuclei, large nucleoli, mitoses identified Micropapillary architecture All four cases had associated cystic hypersecretory hyperplasia
- Four cases reported with cytologic atypia, of unknown clinical significance (Shin)
- Intraluminal calcifications described (Shin)
Smooth contours, frequent eosinophilic border, uneven laminations “Precalcified” laminated proteinaceous deposits described
