Surgical Pathology Criteria

Perilobular Hemangioma of the Breast

Differential Diagnosis

Angiosarcoma of the Breast Perilobular Hemangioma
Almost always a hemorrhagic mass >2 cm Microscopic, incidental lesion
Diffuse, infiltrating Localized
Complex anastomoses No complex anastomoses
Intermediate and high grade tumors are cytologically atypical No significant cytologic atypia
Frequent papillae or tufting No papillae or tufting
Complete excision and examination are required to insure accurate diagnosis of an apparently benign vascular lesion in the breast


Perilobular Hemangioma Pseudoangiomatous Stromal Hyperplasia
Endothelial lined spaces No true lining to spaces
CD31 positive CD31 negative
Red blood cells in some spaces No red blood cells in spaces
Both are usually incidental findings


Angiomatosis Perilobular Hemangioma Hemangioma Venous Hemangioma
Mass lesion Microscopic, incidental lesion Mass lesion Mass lesion
Diffuse, infiltrating Localized Localized Localized
Cavernous Predominantly capillary Usually cavernous Cavernous
Complete excision and examination is required for the diagnosis of any benign vascular lesion in the breast

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