Nipple Adenoma of the Breast
Differential Diagnosis
- Ductal adenoma, Radial scar and Sclerosing adenosis
- Infiltrating syringomatous adenoma of the nipple
- Papilloma
- Tubular adenoma
Radial Scar, Sclerosing Adenosis, Ductal Adenoma and Nipple Adenoma
- May be considered a spectrum of lesions differing in location and predominant pattern
- All are benign
| Nipple Adenoma | Infiltrating Syringomatous Adenoma of the Nipple |
|---|---|
| May have compressed ducts at edges but predominantly papillomatous | Irregular, frequently compressed lumens throughout |
| Localized although not completely circumscribed | Infiltrative |
| Stroma non-reactive | Desmoplastic stroma |
| Nipple Adenoma | Intraductal Papilloma |
|---|---|
| Hyperplastic lesion with papillomatosis and/or adenosis | Papillary fronds lacking florid hyperplasia |
| Nipple Adenoma | Tubular Adenoma |
|---|---|
| Frequent prominent sclerosing stroma | Scant stroma |
| Localized but not completely circumscribed | Completely sharply circumscribed |
| Papillomatosis or adenomatosis with variable small glands | Uniform glands |
