Nipple Adenoma of the Breast
Definition
- Florid benign proliferation of nipple ductal epithelium
Alternate / Historical names
- Erosive adenomatosis of the nipple
- Florid papillomatosis of the nipple ducts
- Nipple duct adenoma
- Papillary adenoma of the nipple
Diagnostic Criteria
- Florid epithelial proliferation with papillomatosis, adenosis or mixed pattern
- Papillomatosis
- Papillary hyperplasia of duct lining cells
- Solid tufts and growths
- Lacks true fibrovascular cores
- Crowded, distorted
- Occasional necrosis
- Adenosis
- Densely packed small glands or tubules
- May have prominent sclerosing component
- Distorts epithelial component
- Frequently zonal, with central sclerosis
- Epithelial component accentuated in periphery
- Cytologically bland
- Myoepithelial cells uniformly present
- Surround papillomatous growths
- Surround small glands/tubules
- Features frequently seen in all patterns
- Apocrine metaplasia
- Extension of glandular component onto surface epithelium
- Squamous cysts at junction with surface
- Acanthosis
- Intralumenal multinucleated giant cells
- Lesion centered on lactiferous ducts
- Identical lesion in subareolar location is sometimes termed Subareolar Sclerosing Duct Hyperplasia
- Lacks squamous cysts
- Typically more nodular than stellate
