Low Grade Neuroendocrine Carcinoma of the Breast
Differential Diagnosis
- Metastatic neuroendocrine carcinoma must be ruled out clinically
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Neuroendocrine Carcinomas: Low Grade, High Grade or NOS
- Low grade neuroendocrine carcinoma by definition has low grade cytologic features
- Round, regular to mildly irregular nuclei up to 2-3x the size of a RBC
- No comedo necrosis
- Neuroendocrine carcinoma NOS
- Lacks the specific features of the other two
- High grade neuroendocrine carcinoma
- Most demonstrate features of small cell carcinoma
- Very rare carcinomas have been reported that demonstrate features similar to pulmonary large cell neuroendocrine carcinomas
- Low grade neuroendocrine carcinoma by definition has low grade cytologic features
