Surgical Pathology Criteria

Myoepithelioma of the Breast

Differential Diagnosis

 

Adenomyoepithelioma Myoepithelioma
Biphasic with myoepithelial and tubular components Purely myoepithelial, may surround normal ducts
Circumscribed May be stellate

 

Myoepithelial Carcinoma Myoepithelioma
Cytologically malignant Cytologically bland
Frequent mitotic figures Mitotically inactive
Necrosis may be present No necrosis

 

Myofibroblastoma Myoepithelioma
Circumscribed May be stellate
Keratini negative Keratin positive
CD34 positive CD34 not reported but expected to be negative

 

Metaplastic Carcinoma Myoepithelioma
Contains malignant epithelial component No epithelial component
Mesenchymal component, if present is usually cytologically malignant Bland spindle cell population

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