Invasive Micropapillary Carcinoma of the Breast
Supplemental Studies
Immunohistology
- Reported phenotype of micropapillary carcinomas
E-cadherin 100% GCDFP15 50% ER/PR 20-90% Her2neu 35-100% p53 40-70% CK7 83% CK20 0%
Immunohistochemistry of micropapillary carcinomas of various sites
| CK7 | CK20 | GCDFP15 | ER | PR | TTF1 | |
|---|---|---|---|---|---|---|
| Bladder | 100% | 90% | ND | ND | ND | ND |
| Breast | 83% | 0% | 50% | 20-90% | 20-90% | ND |
| Large Intestine | 0% | 100% | ND | ND | ND | ND |
| Lung | 93% | 13% | ND | ND | ND | 80% |
| Salivary Gland | 100% | 0% | 83% | 8% | 8% | ND |
| Ovary | 100% | 15% | <5% | 100% | 90% | 1% |
Prognostic/Therapeutic Markers
- Estrogen receptor (ER) and progesterone receptor (PR) are important markers for directing therapy and determining prognosis
- Current consensus is that any level of positivity should be reported as positive
- Her2neu status can be determined by either immunohistology or by FISH
- The other technique can be used for borderline case
Genetic analysis
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Her2neu status can be determined by either immunohistology or by FISH
- The other technique can be used for borderline cases
