Surgical Pathology Criteria

Invasive Micropapillary Carcinoma of the Breast

Differential Diagnosis

Usual infiltrating carcinoma with retraction artifact

 

Usual infiltrating carcinoma with extensive lymphovascular invasion

 

Mucinous Carcinoma Micropapillary Carcinoma
Prominent mucin in spaces Spaces generally clear with infrequent, scant stainable mucin
Irregular epithelial clusters Numerous, relatively uniform clusters, one or a few per space
Usually low grade cytology Frequently high grade cytology

Immunohistochemistry of micropapillary carcinomas of various sites

  CK7 CK20 GCDFP15 ER PR TTF1
Bladder 100% 90% ND ND ND ND
Breast 83% 0% 50% 20-90% 20-90% ND
Large Intestine 0% 100% ND ND ND ND
Lung 93% 13% ND ND ND 80%
Salivary Gland 100% 0% 83% 8% 8% ND
Ovary 100% 15% <5% 100% 90% 1%
No data available on ampullary/pancreatic/biliary tumors

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