Microglandular Adenosis of the Breast
Supplemental Studies
Immunohistology
| S100 |
100% diffuse |
| CK8/18 |
100% |
| EGFR |
100% |
| EMA |
Negative |
| GCDFP15 |
Negative |
| CK5/6 |
Negative |
| Smooth muscle actin |
Negative |
| ER, PR |
Negative |
| Her2neu |
Negative |
| CD117 |
Negative |
| Collagen type IV |
Positive basement membrane |
| Ki67 |
<3% |
| p53 |
<3% |
CD117 may be positive in associated CIS or carcinoma
- Ki67 and p53: 5-10% in microglandular adenosis with atypia, >30% in carcinoma
Histochemistry
- Lumenal secretion positive for PASd and other mucin stains
