Microglandular Adenosis of the Breast
Definition
- A haphazard proliferation of uniform, cytologically bland glands
Diagnostic Criteria
- Small, uniform open round glands
- Lined by uniform cuboidal to slightly flat cells
- Nuclei frequently flat, parallel to circumference of gland
- Clear to eosinophilic cytoplasm
- Lumenal eosinophilic colloid-like secretion
- Occasional lumenal calcification
- Cytologically bland
- Small indististinct nucleoli
- MItotic figures uncommon
- Haphazard distribution
- Poorly circumscribed
- No lobular grouping
- Not stellate
- Frequently overruns normal elements
- No perineural or vascular invasion
- Background of fibrous or fatty tissue
- No spindle cell or desmoplastic component
- No myoepithelial layer
