Metaplastic Carcinoma of the Breast
Supplemental Studies
Immunohistology
- From a diagnostic standpoint the important distinction is from sarcoma
- p63 and CK5/6 appear to be quite specific for this
- Laminin 5 appears more sensitive but more data is needed regarding its specificity
- It is important to be aware of significant smooth muscle actin and S100 reactivity
- Their presence does not rule out carcinoma
| Laminin 5 |
96% |
| p63 |
57-86% |
| CK5/6 |
50-86% |
| CD10 |
85% |
| Smooth muscle actin |
60% |
| S100 |
45% |
Squamous and mesenchymal elements and in most cases ductal elements all stained
