Medullary Carcinoma of the Breast
Clinical
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Rare type of carcinoma utilizing strict criteria
- Early reports indicated a significantly better prognosis than high grade infiltrating ductal carcinoma as long as nodes are negative
- Some recent studies do not confirm this improved prognosis
- Problems with interobserver reproducibility and with adherence to strict criteria may explain these variable reports
- A minority of cases may be associated witih germ line BRCA1 mutations
- Recurrences are very rare more than 5 years post detection
