Surgical Pathology Criteria

Gynecomastia-like Lesion of the Female Breast

Differential Diagnosis

Mammary Hamartoma Gynecomastia-like Lesion of the Female Breast
Circumscribed Not circumscribed
Contains lobules No lobules
No periductal stromal changes Periductal stromal fibrosis or edema
May contain stromal smooth muscle or cartilage No stromal smooth muscle or cartilage

 

Pubertal Macromastia Gynecomastia-like Lesion of the Female Breast
Diffuse, massive enlargement Focal lesion or area
Lobules are typically absent (or poorly formed) in both

 

Gynecomastia-like lesion lacks the circumscription of fibroadenoma or juvenile fibroadenoma

 

Gynecomastia-like lesion probably falls within the spectrum of fibrocystic disease but differs from the usual by its distinct periductal stroma and its lack of lobules

 

Micropapillary Ductal Carcinoma In Situ Gynecomastia-like Lesion of Female Breast
Micropapillae have bulbous, expanded ends Micropapillae have thin tips, wider base
Uniform cells throughout Smaller cells at top
Hyperchromatic throughout Hyperchromatic at top, not base
Often associated with other DCIS patterns Often associated with other hyperplastic patterns

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