Gynecomastia-like Lesion of the Female Breast
Differential Diagnosis
- Mammary Hamartoma
- Pubertal macromastia
- Fibroadenoma and juvenile fibroadenoma
- Fibrocystic disease
- Micropapillary ductal carcinoma in situ
| Mammary Hamartoma | Gynecomastia-like Lesion of the Female Breast |
|---|---|
| Circumscribed | Not circumscribed |
| Contains lobules | No lobules |
| No periductal stromal changes | Periductal stromal fibrosis or edema |
| May contain stromal smooth muscle or cartilage | No stromal smooth muscle or cartilage |
| Pubertal Macromastia | Gynecomastia-like Lesion of the Female Breast |
|---|---|
| Diffuse, massive enlargement | Focal lesion or area |
Gynecomastia-like lesion lacks the circumscription of fibroadenoma or juvenile fibroadenoma
Gynecomastia-like lesion probably falls within the spectrum of fibrocystic disease but differs from the usual by its distinct periductal stroma and its lack of lobules
| Micropapillary Ductal Carcinoma In Situ | Gynecomastia-like Lesion of Female Breast |
|---|---|
| Micropapillae have bulbous, expanded ends | Micropapillae have thin tips, wider base |
| Uniform cells throughout | Smaller cells at top |
| Hyperchromatic throughout | Hyperchromatic at top, not base |
| Often associated with other DCIS patterns | Often associated with other hyperplastic patterns |
