Granulomatous Lobular Mastitis
Definition
-
Granulomatous lobulocentric inflammation nearly always associated with a prior pregnancy
Alternate/Historical Names
- Granulomatous mastitis
- Postlactational granulomatous mastitis
Diagnostic Criteria
- Granulomatous inflammation
- Multinucleated giant cells
- Epithelioid histiocytes
- Occasional features
- Fat necrosis
- Abscesses
- Sinus tract
- Eosinophils
- Schaumann and asteroid bodies absent to rare
- Centered on lobules
- Extensive inflammation may obliterate lobulocentric character
- Ductal and periductal inflammation usually minor
- Nearly always follows pregnancy
- Mean interval two years
- Rarely remote
- Has been associated with oral contraceptive use
