Surgical Pathology Criteria

Glycogen Rich Clear Cell Carcinoma of the Breast

Differential Diagnosis

Glycogen Rich Clear Cell Carcinoma Lipid Rich Carcinoma
PAS positive, diastase sensitive glycogen PAS negative
Lipid stain negative Lipid stain positive
Clear cytoplasm Cytoplasm clear to multivacuolated

 

Glycogen Rich Clear Cell Carcinoma Secretory Carcinoma
PAS positive, diastase sensitive glycogen PASd positive mucin
Cytology may be of any grade Low grade cytology
No predilection for younger patients Most cases <30 years
Behavior is that of usual invasive carcinoma Excellent prognosis

 

Metastatic Renal Cell Carcinoma

 

PEComa / Sugar Cell Tumor

 

Glycogen Rich Clear Cell Carcinoma Eccrine Acrospiroma (Clear Cell Hidradenoma)
Intraparenchymal Superficial
May have an intraductal component No intraductal component
Single cell type Two cell types
No squamous differentiation Squamous eddies may be present
May have any degree of cytologic atypia Low grade cytology

 

Glycogen Rich Clear Cell Carcinoma Adenomyoepithelioma
Single cell type Two cell types
No neoplastic myoepithelial cell component Neoplastic myoepithelial component present
Clear cytoplasm in all areas Clear cells confined to myoepithelial cells

Stanford Medicine Resources:

Footer Links: