Fibroadenoma of the Breast

Clinical

Peak age in twenties
- Uncommon after menopause
  - Frequently smaller and hyalinized
Multiple in 25% of patients

Relative risk for development of invasive breast carcinoma

No increased risk
- Non-proliferative fibrocystic change
- Fibroadenoma
- Solitary papilloma
Slightly increased risk (1.5 to 2 times)
- Proliferative fibrocystic change
- Usual ductal hyperplasia
- Sclerosing adenosis (florid)
- Radial scar
- Complex fibroadenoma (approximately 3 times risk)
Moderately increased risk (4 to 5 times)
- Atypical ductal hyperplasia (no family history)
- Atypical lobular hyperplasia
High risk (8 to 10 times)
- Ductal carcinoma in situ, low grade
- Lobular carcinoma in situ
- Atypical ductal hyperplasia, if history of carcinoma in primary relatives
Very high risk (precise level not known)
- Ductal carcinoma in situ, high grade