Nearly all reported cases with full constellation of histologic features have occurrred in diabetics
Most often associated with Type I diabetes
One report of association with longstanding insulin use rather than type of diabetes (Seidman)
Occasional cases reported in non-diabetics with some but not all of the diagnostic histologic features
Significance of such lesions is unclear
Autoantibodies reported in some cases (Schwartz)
Generally presents as a fibrous mass or masses
May be unilateral or bilateral
One prospective series of diabetics found non-palpable lesions with some but not all of the diagnostic histologic features (Lammie)
Most patients female
Virtually all premenopausal
Rare male cases reported
Valdez R, Thorson J, Finn WG, Schnitzer B, Kleer CG. Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases. Mod Pathol. 2003 Mar;16(3):223-8.
Ely KA, Tse G, Simpson JF, Clarfeld R, Page DL. Diabetic mastopathy. A clinicopathologic review. Am J Clin Pathol. 2000 Apr;113(4):541-5.
Tomaszewski JE, Brooks JS, Hicks D, Livolsi VA. Diabetic mastopathy: a distinctive clinicopathologic entity. Hum Pathol. 1992 Jul;23(7):780-6.
Schwartz IS, Strauchen JA. Lymphocytic mastopathy. An autoimmune disease of the breast? Am J Clin Pathol. 1990 Jun;93(6):725-30.
Lammie GA, Bobrow LG, Staunton MD, Levison DA, Page G, Millis RR. Sclerosing lymphocytic lobulitis of the breast--evidence for an autoimmune pathogenesis. Histopathology. 1991 Jul;19(1):13-20.
Morgan MC, Weaver MG, Crowe JP, Abdul-Karim FW. Diabetic mastopathy: a clinicopathologic study in palpable and nonpalpable breast lesions. Mod Pathol. 1995 May;8(4):349-54.
Ashton MA, Lefkowitz M, Tavassoli FA. Epithelioid stromal cells in lymphocytic mastitis--a source of confusion with invasive carcinoma. Mod Pathol. 1994 Jan;7(1):49-54.
Seidman JD, Schnaper LA, Phillips LE. Mastopathy in insulin-requiring diabetes mellitus. Hum Pathol. 1994 Aug;25(8):819-24.
Fong D, Lann MA, Finlayson C, Page DL, Singh M. Diabetic (lymphocytic) mastopathy with exuberant lymphohistiocytic and granulomatous response: a case report with review of the literature. Am J Surg Pathol. 2006 Oct;30(10):1330-6.