Diabetic Mastopathy / Lymphocytic Mastitis
Definition
-
A fibrous breast mass witha prominent lymphocytic infiltrate most often occurring in patients with longstanding diabetes
Alternate/Historical Names
- Diabetic fibrous mastopathy
- Diabetic lymphocytic lobulitis
- Fibrous disease of the breast in juvenile diabetics
- Lymphocytic mastopathy
- Sclerosing lymphocytic lobulitis
Diagnostic Criteria
- Prominent keloidal fibrosis
- Prominent lymphocytic infiltrate
- Perivascular, perilobular, periductal
- May infiltrate lobular epithelium forming lymphoepithelial lesions
- Sharply circumscribed infiltrate
- May form nodules but germinal centers not seen
- Predominantly B cells
- One case reported of a postmenopausal patient with an exuberant lymphohistiocytic and granulomatous response (Fong 2006)
- Epithelioid stromal cells
- No mitotic figures described in stromal cells
- Variable staining for actin
- No epithelial proliferation
- Virtually all female patients premenopausal
- Nearly all reported cases with the full constellation of histologic features have occurred in diabetics
