Surgical Pathology Criteria

Cribriform Carcinoma of the Breast

Differential Diagnosis

Tubular Carcinoma vs Cribriform Carcinoma

Adenoid Cystic Carcinoma Cribriform Carcinoma
Cores of PASd positive basement membrane No basment membrane cores
Myoepithelial component present No myoepithelial component
ckit positive population No ckit positivity
Estrogen receptor generally negative Estrogen receptor uniformly positive
No DCIS DCIS may be present
Low grade cribriform carcinoma and adenoid cystic carcinoma both have nearly 100% survival

Cribriform Carcinoma Collagenous Spherulosis
Grossly visible or palpable lesion Nearly always an incidental microscopic finding
Invasive architecture Circumscribed, intraductal or intralobular
May have intralumenal mucin but lacks fibrillar or laminated appearance Frequently fibrillar or laminated spherules
Lacks myoepithelial component Myoepithelial cells surround spherules
Nuclei slightly enlarged compared to normal (2-3 times larger than RBC) Nuclei identical in size and appearance to normal

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