May have intralumenal mucin but lacks fibrillar or laminated appearance
Frequently fibrillar or laminated spherules
Myoepithelial component restricted to peripheral layer of duct
Myoepithelial cells surround spherules
Nuclei slightly enlarged compared to normal (2-3 times larger than RBC)
Nuclei identical in size and appearance to normal
Three large series with age range 36-90, mean about 50 years
Nearly always an incidental histologic finding
One reported palpable case
May be associated with microcalcifications
Benign finding with no known significance
May be associated with other lesions of significance
Grading / Staging / Report
Grading and staging are not applicable
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