Surgical Pathology Criteria

Apocrine Adenosis of the Breast

Differential Diagnosis

 

Sclerosing Adenosis with Apocrine Metaplasia Apocrine Adenosis
Cellular, sclerotic stroma Stroma predominantly adipose
Lobular Haphazard
Small glands Variable, larger glands
Compressed lumens Open lumens
No association with adenomyoepithelioma Usually associated with adenomyoepithelioma

 

Apocrine Adenosis Microglandular Adenosis
Myoepithelial layer present, may be hyperplastic No myoepithelial cells
Variable size and shape of glands Uniform round glands
Apocrine lumenal differentiation and in some cases squamous metaplasia present No squamous or apocrine metaplasia
EMA and GCDFP15 positive EMA and GCDFP15 negative

 

Apocrine Adenosis Tubular Adenosis
Variable but round glands Tubules
Apocrine lumenal differentiation and in some cases squamous metaplasia present No squamous or apocrine metaplasia
Frequently merges with adenomyoepithelioma No association with adenomyoepithelioma

 

Apocrine Carcinoma Apocrine Adenosis
Large vesicular nuclei with prominent nucleoli Small bland nuclei
No myoepithelial layer Myoepithelial layer present

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