Apocrine Adenosis of the Breast
Differential Diagnosis
| Sclerosing Adenosis with Apocrine Metaplasia |
Apocrine Adenosis |
| Cellular, sclerotic stroma |
Stroma predominantly adipose |
| Lobular |
Haphazard |
| Small glands |
Variable, larger glands |
| Compressed lumens |
Open lumens |
| No association with adenomyoepithelioma |
Usually associated with adenomyoepithelioma |
| Apocrine Adenosis |
Microglandular Adenosis |
| Myoepithelial layer present, may be hyperplastic |
No myoepithelial cells |
| Variable size and shape of glands |
Uniform round glands |
| Apocrine lumenal differentiation and in some cases squamous metaplasia present |
No squamous or apocrine metaplasia |
| EMA and GCDFP15 positive |
EMA and GCDFP15 negative |
| Apocrine Adenosis |
Tubular Adenosis |
| Variable but round glands |
Tubules |
| Apocrine lumenal differentiation and in some cases squamous metaplasia present |
No squamous or apocrine metaplasia |
| Frequently merges with adenomyoepithelioma |
No association with adenomyoepithelioma |
