Adenoid Cystic Carcinoma of the Breast

Supplemental Studies

Laminin and Collagen type IV surround basement membrane cores
Estrogen and Progesterone Receptors negative in most studies
- Some reports of positivity:
  - 3/20 in study of Mastropasqua 2005, but none over 5%
  - 5/19 in study of Kleer 1998, but series included higher grade tumors
Her2neu negative
Reports of ckit (CD117) expression in myoepithelial component are conflicting
- Mastropasqua reports them to be negative
- Azoulay and Crisi report them to be negative in cribriform pattern but positive in diffuse pattern
  - Published figures of Azoulay look positive in both patterns
- Rabban reports positivity only in lumenal (ductal) cells