Surgical Pathology Criteria

Adenoid Cystic Carcinoma of the Breast

Differential Diagnosis

Adenoid Cystic Carcinoma Cribriform Carcinoma
Cores of PASd positive basement membrane No basment membrane cores
Myoepithelial component present No myoepithelial component
ckit positive population No ckit positivity
Estrogen receptor generally negative Estrogen receptor uniformly positive
No DCIS DCIS may be present
Low grade cribriform carcinoma and adenoid cystic carcinoma both have nearly 100% survival
Adenoid Cystic Carcinoma Collagenous Spherulosis
Grossly visible or palpable lesion Nearly always an incidental microscopic finding
Invasive architecture Circumscribed, intraductal or intralobular
Uniform cores of basement membrane material Variable, frequently fibrillar spherules
Nuclei slightly enlarged compared to normal Nuclei identical in size and appearance to normal
CD117 positive lumenal cells CD117 negative
Calponin, smooth muscle myosin negative (even myoepithelial component) Calponin, smooth muscle myosin positive
Both contain myoepithelial and epithelial components

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