Papillary Urothelial (Transitional Cell) Carcinoma
Supplemental Studies
Immunohistology
- Most cases positive for p63, high molecular weight keratin and GATA3
- May be useful for separation from high grade prostate carcinoma local spread
- Of the three markers, only GATA3 is useful for separation from squamous carcinoma
- Lung SCC negative
- Anal and cervical SCC 20% positive but focal or weak
- High grade urothelial carcinoma 70% moderate to strong diffuse positive
- Thrombomodulin is variably positive in lung SCC
- Uroplakin has low sensitivity for high grade invasive urothelial carcinoma (20-60%)
