Tubules/acini generally more variable in size and distribution
Cytologically quite bland
Nucleoli inconspicuous if present
Nucleoli may be prominent
PSA and PrAP negative
Prostate markers positive in virtually all gland forming prostatic adenocarcinomas
Can be a problem especially in the prostatic urethra, or post surgery/TURP (papillae frequently lost) and because both are racemase/AMACR positive and p63 and HMWCK negative (at least focally in some cases)
Metastatic/direct spread of non-bladder adenocarcinomas
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