Small Lymphocytic Lymphoma / Chronic Lymphocytic Leukemia
Supplemental Studies
Immunohistology and Flow Cytometry
| B lineage |
100% |
| Immunoglobulin |
Variably detectable |
| CD23 |
85% |
| CD5 |
80% |
| bcl2 |
95% |
| CD43 |
80% |
| bcl1 |
2% |
| CD10 |
Negative |
| CD38 |
33% |
| ZAP70 |
36% |
| FMC7 |
Negative |
- Cases with transformation to diffuse large cell lymphoma show the same phenotype as SLL/CLL
- CD38 and ZAP70 reactivity may predict behavior (Hus 2006)
Laboratory Studies
- Serum or urine electrophoresis, immunofixation, light chain quantification
- Small M component (serum monoclonal immunoglobulin) may be present
- Mu heavy chain disease variant
- Serum protein electrophoresis reveals Mu polymers
- Urine protein electrophoresis: 50% show monoclonal free light chain (Bence Jones protein)
