Primary Effusion Lymphoma
Supplemental Studies
Immunohistology
- CD45RB positive
- B lineage markers CD20, CD79a frequently negative
- Immunoglobulin frequently negative
- CD3 rare aberrant positive
- HHV8 positive
- EBV LMP negative
- CD30 positive
- CD38 and CD138 positive
Genetic analysis
-
EBV EBER in situ hybridization positive in HIV patients
- May be negative in HIV negative patients
- HHV8 positive
- Immunoglobulin gene rearrangement positive
- Aberrant T cell receptor gene rearrangement may be seen
