Primary Effusion Lymphoma
Differential Diagnosis
Both are EBV positive. One HHV8+ pyothorax associated lymphoma has been reported by O'Donovan et al.
| Pyothorax Associated Lymphoma | Primary Effusion Lymphoma |
|---|---|
| Associated with chronic inflammation | No association with inflammation |
| No association with immunosuppression | Majority associated with immunosuppression |
| HHV8 negative | HHV8 positive |
| Pleural mass | No mass lesion |
| Plasmablastic Lymphoma | Primary Effusion Lymphoma |
|---|---|
| Not body cavity based (frequently oral cavity) | Involves body cavity |
| CD45RB weak to negative | CD45RB positive |
| HHV8 only if associated with Castleman disease | HHV8 positive |
