Surgical Pathology Criteria

Primary Mediastinal (Thymic) Large B Cell Lymphoma

Differential Diagnosis

 

Classical Hodgkin lymphoma vs. Mediastinal Large B Cell Lymphoma

  Classical Hodgkin Lymphoma Mediastinal B Cell Lymphoma
CD20 20% >90%
CD79a 10% >90%
LCA/CD45RB 10% >90%
CD15 80% 4%
CD30 90% 69%
Light chains polytypic or negative monotypic or negative

 

Thymoma vs. Mediastinal B Cell Lymphoma

Thymic carcinoma vs. Mediastinal B Cell Lymphoma

Sclerosing mediastinitis vs. Mediastinal B Cell Lymphoma

Germ Cell Tumor vs. Mediastinal B Cell Lymphoma

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