Primary Mediastinal (Thymic) Large B Cell Lymphoma
Clinical
- Mean age 25-30 years but wide range
- Female : Male 2:1
- Frequent obstruction of superior vena cava or trachea
- Frequent (26%) CNS involvement, primarily on relapse
- Lamarre has suggested that there are two types of mediastinal B cell lymphoma
- Immunoglobulin negative, predominantly female, younger
- Immunoglobulin positive, no sex preference, older
- The prognosis of primary mediastinal B cell lymphoma has been debated
- Some series have found aggressive clinical behavior and a poor prognosis
- Others indicate a similar prognosis to that of other non-mediastinal B cell lymphomas
