Surgical Pathology Criteria

Mantle Cell Lymphoma

Supplemental Studies

Immunohistology and Flow Cytometry

B lineage 100%
Immunoglobulins Variably detectable
bcl1 (cyclinD1) 85%
CD5 80%
CD43 85%
CD23 2%
bcl2 95%
CD10 2%
bcl1 negative cases may have cyclinD2 (CCND2) or cyclinD3 (CCND3) expression detectable by immunohistochemistry

Ki67 should be performed and reported in every case as the % positive is related to survival
Ki67 rate 5 year survival
5-20% 47%
21-40% 32%
41-60% 31%
61-90% 25%
Katzenberger 2006

 

Genetic Analysis

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