Lymphoplasmacytic Lymphoma
Supplemental Studies
Immunohistology and Flow Cytometry
- B lineage 100%
- Light chain monotypia and heavy chains reliably detectable in plasmacytoid cells
- IgM 67%
- IgG 33%
- IgA very rare
- Immunoglobulin light and heavy chains variably detectable in small cells
- bcl2 >50%
- CD43 10-30%
- Lacks specific markers of other lymphoma types
- CD5 5%
- bcl1 negative
- CD10 3%
- CD23
- 0-30% by immunohistology
- Flow results reported up to 60% but weak
- CD138 100%
- FMC7 38%
Clinical Laboratory
- IgM monoclonal spike (>3 gm/dl) in 100%
