Lymphoplasmacytic Lymphoma
Clinical
- Mean age 60 years, rare before 30
- 100% have monoclonal serum or urine IgM
- Typically exhibit findings of Waldenstrom macroglobulinemia
- Hyperviscosity
- Autoimmune hemolytic anemia and thrombocytopenia
- Cryoglobulinemia
- Neuropathy
- Rare cases make a defective, non-secreted IgM
- Rare gamma heavy chain variant
- Very rare alpha heavy chain production
- More frequent extranodal disease than SLL/CLL
- Increased circulating lymphocytes variably reported from 0-30%
- 50% 4 year survival
- May be associated with Hepatitis C
- 30% incidence of Hepatitis C reported
- So far, only reported from Italy
