Lymphomatoid Granulomatosis Variant of Diffuse Large B Cell Lymphoma

Grading / Staging / Report

Grade I
- No large atypical cells
- Little necrosis
- EBV in situ+ cells rare
- Some cases spontaneously resolve
Grade II
- Occasional large atypical cells
- Moderate necrosis
- EBV in situ+ cells 5-20/hpf
- Some cases spontaneously resolve
Grade III
- Predomiant population of large atypical cells
  - May be confluent
- Extensive necrosis

Low grade
- Few large atypical cells
- Few mitotic figures
- Little necrosis
- Some cases spontaneously resolve
High grade
- Predomiant population of large atypical cells
- Extensive necrosis

Stage IV by definition
Stage I
- I if involvement of a single lymph node region
- IE if involvement of a single extralymphatic organ or site
Stage II
- II if two or more lymph node regions on same side of diaphragm
- IIE if localized involvement of an extralymphatic organ or site and one or more lymph node regions on the same side of the diaphragm
Stage III
- III if Involvement of lymph node regions on both sides of the diphragm
- IIIS if spleen involved
- IIIE if extralymphatic site involved
Stage IV
- Diffuse or disseminated involvement of one or more extralymphatic organs or tissues, with or without associated lymph node involvement
Systemic Symptoms in 6 months preceding admission
- Fever, night sweats, 10% weight loss
- A = absent
- B = present
Extranodal sites are also designated
- M+ = marrow
- L+ = lung
- H+ = liver
- P+ = pleura
- O+ = bone
- D+ = skin and subcutaneous tissue
Although originally designed for Hodgkin lymphoma, the Ann Arbor System is also used for non-Hodgkin lymphomas.

Diagnosis in the World Health Organization (WHO) classification
- Equivalent diagnosis in other classifications used by relevant clinicians
Results of supplementary studies if performed
Relationship to other specimens from the same patient
Information relevant to staging if available