Lymphomatoid Granulomatosis
Supplemental Studies
Immunohistology
- Large atypical cells
- B lineage (CD20, CD79a+)
- EBV LMP positive but much less reliable than in situ hybridization
- CD30 variable
- CD15 negative
- Small cells
- T cell phenotype
- May be predominant population
Genetic analysis
-
EBV EBER positive by in situ hybridization
- Required for diagnosis
- Immunoglobulin gene rearrangements
- Variable in grade I lesions
- Present in grade II or III lesions
