KSHV-associated Germinotropic Lymphoproliferative Disorder
Differential Diagnosis
| Plasmablastic Lymphoma | KSHV-associated Germinotropic Lymphoproliferative Disorder |
|---|---|
| Typically oral cavity | Localized lymphadenopathy |
| Immunosupressed patient | Immunocompetent patient |
| Sheets of plasmablasts | Plasmablasts involve germinal centers |
| Some cases associated with multicentric Castleman disease (MCD) | No Castleman features in follicles |
| EBV 50% positive | EBV positve |
Both may partially replace the node and be negative or minimally reactive for CD20 and CD45RB
| Diffuse Large B Cell Lymphoma | KSHV-associated Germinotropic Lymphoproliferative Disorder |
|---|---|
| Typically effaced architecture | Overall nodal architecture preserved |
| Typically sheets of large atypical cells | Follicular pattern |
| HHV8 and EBV negative except in immunosuppressed patients | HHV8 and EBV positive |
| Anaplastic Large Cell Lymphoma | KSHV-associated Germinotropic Lymphoproliferative Disorder |
|---|---|
| Sinusoidal pattern | Follicular pattern |
| ALK positive 60-85% | ALK negative |
| HHV8 and EBV negative | HHV8 and EBV positive |
| T lineage (T cell receptor) | B lineage (light chain expression) |
