Surgical Pathology Criteria

KSHV-associated Germinotropic Lymphoproliferative Disorder

Differential Diagnosis

 

Plasmablastic Lymphoma KSHV-associated Germinotropic Lymphoproliferative Disorder
Typically oral cavity Localized lymphadenopathy
Immunosupressed patient Immunocompetent patient
Sheets of plasmablasts Plasmablasts involve germinal centers
Some cases associated with multicentric Castleman disease (MCD) No Castleman features in follicles
EBV 50% positive EBV positve
Plasmablasts are the lesional cells in both disorders and both may be HHV8 positive


Both may partially replace the node and be negative or minimally reactive for CD20 and CD45RB

Diffuse Large B Cell Lymphoma KSHV-associated Germinotropic Lymphoproliferative Disorder
Typically effaced architecture Overall nodal architecture preserved
Typically sheets of large atypical cells Follicular pattern
HHV8 and EBV negative except in immunosuppressed patients HHV8 and EBV positive


Anaplastic Large Cell Lymphoma KSHV-associated Germinotropic Lymphoproliferative Disorder
Sinusoidal pattern Follicular pattern
ALK positive 60-85% ALK negative
HHV8 and EBV negative HHV8 and EBV positive
T lineage (T cell receptor) B lineage (light chain expression)
Both share cytologic features, may partially replace the node with clusters of large atypical cells and may be negative or minimally reactive for CD45RB

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