Intravascular Large Cell Lymphoma
Ann Arbor Staging System
(Intravascular lymphoma is typically Stage IV at presentation)
- Stage I
- I if involvement of a single lymph node region
- IE if involvement of a single extralymphatic organ or site
- Stage II
- II if two or more lymph node regions on same side of diaphragm
- IIE if localized involvement of an extralymphatic organ or site and one or more lymph node regions on the same side of the diaphragm
- Stage III
- III if Involvement of lymph node regions on both sides of the diphragm
- IIIS if spleen involved
- IIIE if extralymphatic site involved
- Stage IV
- Diffuse or disseminated involvement of one or more extralymphatic organs or tissues, with or without associated lymph node involvement
- Systemic Symptoms
in 6 months preceding admission
- Fever, night sweats, 10% weight loss
- A = absent
- B = present
- Extranodal sites are also designated
- M+ = marrow
- L+ = lung
- H+ = liver
- P+ = pleura
- O+ = bone
- D+ = skin and subcutaneous tissue
- Although originally designed for Hodgkin lymphoma, the Ann Arbor System is also used for non-Hodgkin lymphomas
