Intravascular Large Cell Lymphoma
Differential Diagnosis
Reactive angioendotheliomatosis vs Intravascular Large Cell Lymphoma
| ReactiveAngioendotheliomatosis | Intravascular LargeCell Lymphoma | |
|---|---|---|
| Cytology | Benign | Malignant |
| Lymphoid antigens | Negative | Positive |
| Endothelial antigens(CD31, CD34, Factor VIIIRa, Smooth muscle actin) | Positive | NegativeWeak Factor VIIIRa may be adsorbed from clots |
| Associated bacterial endocarditis | Frequent | Negative |
Metastatic carcinoma and melanoma:
- Occasionally may be intravascular
- Can be identified with stains for keratin, S100 and other markers
