Diffuse Large B Cell Lymphoma

Variant: T Cell Rich B Cell Lymphoma / Histiocyte Rich B Cell Lymphoma

Can be considered as a spectrum
Large atypical cells make up less than 10% of population
- May have any features of usual large B cell lymphoma
- May resemble Reed-Sternberg cells
- B lineage
  - Neoplastic cells may be missed on flow analysis
  - CD30 0-8%
  - CD15 0-15%
  - EMA 0-60%
Reactive T cells predominante
- Small to medium sized
- Nuclei may be round or irregular
- No increase in CD57 positive cells
Histiocytes may be numerous
May be associated with conventional large B cell lymphoma pattern
- May be concurrent or metachronous
Same behavior as conventional diffuse large B cell lymphoma, stage for stage
- Over half present as stage III or IV