Light chain monotypic, variably demonstrable in paraffin
Ki67
100 %
bcl6
100%
CD10
99%
CD43
73%
bcl1
negative
CD5
negative
CD23
negative
CD25
negative
CD30
negative
CD34
negative
CD99
negative
ALK
negative
TdT
negative
bcl2
0-25%
Genetic analysis
EBV EBER identifiable by FISH
Endemic cases nearly 100%
Middle East, North Africa, South America 60-80% of cases
34% of immunodeficiency cases
Sporadic cases <30%
Three major translocations involving myc gene and various Ig genes
t(8;14)(q23;q21)
Approximately 80% of cases
Same translocation present in up to 15% of diffuse large B cell lymphoma
t(8;22)
t(2;8)
Ig heavy and light chains clonally rearranged in all cases
Gene expression profiling shows a Burkitt signature involving c-myc
Some diffuse large B cell lymphomas with this signature show better response to aggressive chemotherapy targeting Burkitt lymphoma rather than standard DLBCL therapy (CHOP or R-CHOP)
