Surgical Pathology Criteria

Precursor B Lymphoblastic Lymphoma

Supplemental Studies

Immunohistology

Genetic analysis

Abnormality Gene fusion Frequency Prognosis

t(9;22)(q34;q11.2)

BCR/ABL

3-4%

Unfavorable

t(4;11)(q21;q23)

AF4/MLL

2-3%

Unfavorable

t(1;19)(q23;q13.3)

PBX/E2A

6% (25% of pre-B type)

Unfavorable

t(12;21)(q13;q22)

TEL/AML1

16-29%

Favorable

Hyperdiploid chromosomes 4,10,17

 

20-25%

Favorable

Hypodiploid

 

5%

Unfavorable

Modified from Brunning et al. in Jaffe 2001

 

Cytochemistry

 

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